《MicroRNAs与癌症》.pdfVIP

Chinese-German Journal of Clinical Oncology September 2010, Vol. 9, No. 9, P547–P554 DOI 10.1007/s10330-010-0648-8 MicroRNAs and cancer 1 2 3 4 5 2 4 6 Libo Xiao , Zhiping Wu , Rui Feng , Qishun Zhu , Chenwei Gao , Yan Chen , Chun Hou , Yonggui Wu 1 Yunnan Red Cross Hospital, Kunming 650021, China 2 School of Chemistry Science and Technology, Yunnan University, Kunming 650091, China 3 Fifth High School of Guandu District, Kunming 650011, China 4 School of Life Science, Yunnan University, Kunming 650091, China 5 Cancer Institute, the 3rd Affiliated Hospital of Kunming Medical College, Kunming 650118, China 6 Department of Base Medicine, Yunnan Chinese Traditional Medical College, Kunming 650200, China Received: 6 June 2010 / Revised: 20 July 2010 / Accepted: 7 August 2010 © Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg 2010 Abstract MicroRNAs (miRNAs) belong to a class of noncoding, regulatory RNAs that are involved in oncogenesis and show remarkable tissue specificity. miRNAs are approximately 22 nt non-coding RNAs, which regulate gene expression in a sequence-specific manner via translational inhibition or messenger RNA (mRNA) degradation, thus affecting various cellular processes. Since the discovery of their fundamental mechanisms of action, the field of miRNAs has opened a new era in the understanding of small noncoding RNAs. Recent evidence has shown that miRNA controls cell growth, apoptosis, and differ- entiation. Cancer is a complex genetic disease caused by abnormalities in gene structure and expression, moreover, miRNA expression correlates with cancers and could have a crucial function in tumor progress