《Longterm administration of scopolamine interferes with nerve cell proliferation differentiation and migration in adult mouse hippocampal dentate gyrus but it does not induce cell death》.pdfVIP

NEURAL REGENERATION RESEARCH October 2014,Volume 9,Issue 19 Long-term administration of scopolamine interferes with nerve cell proliferation, differentiation and migration in adult mouse hippocampal dentate gyrus, but it does not induce cell death 1 2 3 2 2 2 2 4 5 Bing Chun Yan , Joon Ha Park , Bai Hui Chen , Jeong-Hwi Cho , In Hye Kim , Ji Hyeon Ahn , Jae-Chul Lee , In Koo Hwang , Jun Hwi Cho , 3 6 2 Yun Lyul Lee , Il-Jun Kang , Moo-Ho Won 1 Department of Integrative Traditional Western Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu Province, China 2 Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, South Korea 3 Department of Physiology, College of Medicine, Institute of Neurodegeneration and Neuroregeneration, Hallym University, Chuncheon, South Korea 4 Department of Anatomy and Cell Biology, College of Veterinary Medicine, Seoul National University, Seoul, South Korea 5 Department of Emergency Medicine, School of Medicine, Kangwon National University, Chuncheon, South Korea 6 Department of Food Science and Nutrition, Hallym University, Chuncheon, South Korea Abstract Bing Chun Yan and Joon Ha Park Long-term administration of scopolamine, a muscarinic receptor antagonist, can inhibit the contributed equally to this article. survival of newly generated cells, but its effect on the proliferation, differentiation and migration of nerve cells in the adult mouse hippocampal dentate gyrus remain poorly understood. In this Corresponding author: study, we used immunohistochemistry an