Palladium-Catalyzed Crossing-Coupling Reactions in Total Synthesis.pdf

Reviews K. C. Nicolaou et al. Synthetic Methods Palladium-Catalyzed Cross-Coupling Reactions in Total Synthesis K. C. Nicolaou,* Paul G. Bulger, and David Sarlah Keywords: Dedicated to Richard F. Heck CC coupling · cross-coupling · on the occasion of his 74th birthday palladium catalysis · synthetic methods · total synthesis Angewandte Chemie 4442 2005 Wiley-VCH Verlag GmbH Co. KGaA, Weinheim DOI: 10.1002/anie.200500368 Angew. Chem. Int. Ed. 2005, 44, 2 – 89 Angewandte C C Coupling Chemie In studying the evolution of organic chemistry and grasping its From the Contents essence, one comes quickly to the conclusion that no other type of 1. Introduction 4443 reaction plays as large a role in shaping this domain of science than carbon–carbon bond-forming reactions. The Grignard, 2. The Heck Reaction 4445 Diels–Alder, and Wittig reactions are but three prominent exam- ples of such processes, and are among those which have undeni- 3. The Stille Reaction 4452 ably exercised decisive roles in the last century in the emergence of 4. The Suzuki Reaction 4458 chemical synthes