明日叶查尔酮对2型糖尿病大鼠胰岛细胞损伤的防护作用及研究.pdfVIP

f㈣煳 结论： 明日叶查尔酮可降低2型糖尿病大鼠空腹血糖和血清胰岛素，抑制2型糖尿 病大鼠氧化应激和胰岛细胞的损伤，提高胰腺细胞的增殖活性，上调胰岛细胞Bcl．2 蛋白的表达，下调Bax蛋白的表达，对2型糖尿病胰岛细胞的损伤具有一定的防护 作用。 硕士研究生：王先红(卫生毒理学) 指导教师：钟进义教授尹衍玲教授 关键词：查尔酮；2型糖尿病；胰岛细胞；增殖活性；氧化应激；Bcl．2；Bax The effectofashitabachalconeonisletcells in 2 protective ury inj type diabetesrats ABSTRACT the effectsofAshitaba isletcells of ObjectiveTostudyprotective chalcone(AC)on injury 2diabeticrats． t)，pe Method：TakemaleWistarrats60asexperimental forone subjects，adaptablefeeding week．Thenselected10rats as normalcontrol 50fedwith randomly group，theremaining diet combinedwithlowdose ectionof to high-fat intraperitonealinj streptozotocin indeduced2diabetesratsmodel．Timeformodelinducedisfiveweeks．Thenthe type diabetesratswere dividedintofour control randomly groups：diabeticgroup，high，medium and lowdoseAC on group．Basedhigh-fat diet，30mg／(kg‘bw)／d，10mg／(kg·bw)／d， were as doseAC and 5mg／(kg‘bw)／d，0mg／(kg‘bw)ACgavage low，medium，highgroups Diabeticcontrol control fedcommondiet．The group respectively．Normalgrouponly lastedfour experimentweeks．Freeblood Wasmeasured oxidase