血脂康对大鼠急性心肌缺血再灌注损伤的保护作用.pdfVIP

IIllI t f IrllII II lif t flI ＼1733602 结论： 血脂康能通过减轻炎症反应，降低急性心肌缺血再灌注 损伤大鼠的心肌梗死面积，对缺血再灌注损伤具有保护作用。可应用于 冠心病患者，预防无自觉症状的心肌缺血再灌注损伤。 硕士研究生：滕蕾(心血管内科) 指导教师：张雪娟教授 关键词：大鼠；心肌；再灌注损伤；炎症 Abstract theinflammation Objective：To of investigate protection Xuezhikang inratswithacute Ischemia Capsules MyocardialReperfusionInjury． SDratswere dividedintofour Methods：Fortyhealthy randomly groups：A normalcontrol·Theacute ischemia models myocardialreperfusion injury werenot sham the chestandtheleft produced；Boperation：open ratswerenot descendingcoronaryarteries(LADs)ofligated；C．MIRgroup andD LADswere for minutesand Xuezhikanggroup：the ligatedthirty for120minutes．RatsofD weretreatedwith reperfusion group Xuezhikang (O．099／Kg，gastricother weretreatedwiththesame gavage)andgroups amountofsalineforsevenbeforethe theendof days operation．At Infarctsizeswereassessedafter Evansblueand reperfusion，the dyedby chloride。Bloodwereextractedfromthe triphenyltetrazoliumsamples Abdominal CK-MB、 cTnI、 were aorta，MYO、 IL-IO，、IL．18、CRP detecte