“一锅串联法”合成2-[（E）-2-2-氯-1-甲基-3-吲哚基）乙烯基]喹啉-3-羧酸.pdfVIP

第27卷第6期 化 学 研 究 与 应 用 Vol.27,No.6 　第6期 张荣明,等:柴油/ 渣油多重乳液延缓铬溶胶交联体系的制备及稳定性研究 　 2015年6月 ChemicalResearchandApplication June,2015 文章编号:1004-1656(2015)06-0915-04 One-pot,tandem synthesis of(E)-2-(2-(2-chloro-1- methyl-1H-indol-3-yl) vinyl)quinoline-3-carboxylic acid CHANG Ming qin,ZHANG Hong,LI Yang* (Institute of Superfine Chemicals,Bohai University,Jinzhou 121000,Liaoning) Abstract:In this investigation,the first introduction of indole nucleus into 2-styrylquinoline skeleton leading to a new prototype, namely(E)-2-(2-(2-chloro-1-methyl-1H-indol-3-yl)vinyl)quinoline-3-carboxylic acid(3)had been achieved through a simple and efficient one-pot reaction of ethyl 2-(bromomethyl)quinoline-3-carboxylate(4)with 2-chloro-1-methyl-indole-3-carbaldehyde(5). The molecular structure of the newly synthesized compoundwas confirmed on the basis of elemental analysis and spectral data. Keywords:indole;styrylquinoline;carboxylic acid;one-pot tandem reaction;bromomethyl “一锅串联法”合成2-[(E)-2-2-氯-1-甲基-3-吲哚基) 乙烯基]喹啉-3-羧酸 常明琴,张　 红,李　 阳* (渤海大学超精细化学品研究所,辽宁　 锦州　 121000) 摘要:设计了以2-(溴甲基)喹啉-3-甲酸乙酯(4)与2-氯-1-甲基-3-吲哚醛(5)为起始化合物,通过简便有效的 “一锅法”反应,首次将吲哚环引入2-苯乙烯基喹啉骨架模型,从而得到一新颖结构的双杂环化合物,即(E)- 2-(2-(2-氯-1-甲基-1H-3-吲哚基)乙烯基)喹啉-3-羧酸(3),其结构通过波谱数据和元素分析得以证实。 关键词:吲哚;乙烯基喹啉;羧酸;“一锅串联法”反应;溴甲基 中图分类号:O625　 　 文献标志码:A Among the various classes of quinolines,2-styr- Zouhirietal.reportedthesynthesisof new styrylquin- yl-substituted quinolines(SQLs)formed an important oline derivativeswith additional an additional carbox-