《MSC EPC. in vitro》.pdfVIP

Biochemical and Biophysical Research Communications 400 (2010) 284–291 Contents lists available at ScienceDirect Biochemical and Biophysical Research Communications journal homepage: www.else /loc ate/ybbrc Dynamics of bone marrow-derived endothelial progenitor cell/mesenchymal stem cell interaction in co-culture and its implications in angiogenesis A. Aguirre, J.A. Planell, E. Engel ⇑ Institute for Bioengineering of Catalonia (IBEC), Baldiri Reixac 15-21, 08028 Barcelona, Spain Dept. of Material Science and Metallurgical Engineering, Technical University of Catalonia (UPC), ETSEIB, Av. Diagonal 647, 08028 Barcelona, Spain CIBER-BBN, Maria de Luna 11, Ed. CEEI, 50118 Zaragoza, Spain a r t i c l e i n f o a b s t r a c t Article history: Tissue engineering aims to regenerate tissues and organs by using cell and biomaterial-based approaches. Received 4 August 2010 One of the current challenges in the field is to promote proper vascularization in the implant to prevent Available online 21 August 2010 cell death and promote host integration. Bone marrow endothelial progenitor cells (BM-EPCs) and mes- enchymal stem cells (MSCs) are bone marrow resident stem cells widely employed for proangiogenic Keywords: applications. In vivo, they are likely to interact frequently both in the bone marrow and at sites of injury. Bone marrow In this study, the physical and biochemical interactions between BM-EPCs and MSCs in an in vitro co- Endothelial progenitor cell