硝酮糖苷的合成有机铝试剂与芳香醛的反应研究.pdf

目 录 独创性声明 ························································································· ·(I) 中文摘要 ··························································································· ·(II) Abstract ··························································································· ·(Ⅳ) 第一章 硝酮类化合物研究进展 1.1 前言 ································································································ ·1 1.2 硝酮化合物的合成进展 ·································································· ·1 1.2.1 通过氧化的方法制备 ····························································· ·1 1.2.2 通过 N -单取代羟胺制备 ························································ ·4 1.2.3 通过肟制备 ············································································ ·5 1.2.4 通过 N -杂-O -杂环丙烷制备 ·················································· ·7 1.2.5 通过硝基化合物制备 ····························································· ·8 1.2.6 通过含有芳基的亚硝基化合物制备 ····································· ·8 1.2.7 通过其它方法制备 ······························································· ·11 1.3 硝酮化合物在有机合成中的应用 ················································ ·12 1.3.1 生成二聚体 ·········································································· ·12 1.3.2 缩合反应 ·············································································· ·13 1.3.3 加成反应 ·············································································· ·14 1.4 硝酮化合物在生物医药方面的应用 ············································ ·27 1.4.1 硝酮作为自旋捕获剂及其生物活性 ···································· ·27 1.4.2 硝酮作为生物活性化合物的可能机理 ································ ·29 1.4.3 硝酮作为化疗试剂 ······························································· ·29 参考文献 ····························································································· ·32 第二章 硝酮糖苷类化合物的合成