PinX1在结直肠癌中的表达及预后意义螃.pdfVIP

·3202 · 中华临床医师杂志( 电子版)2015 年9 月第9 卷第17 期 Chin J Clinicians(Electronic Edition),September 1,2015,Vol.9,No.17 ·临床论著· PinX1 在结直肠癌中的表达及预后意义 焦南林1 邓文英2 叶晓兵3 张帆1 【摘要】 目的 探讨PinX1 在结直肠癌中的表达及其临床意义。方法 收集83 例结直肠癌和 癌旁组织蜡块，所有患者均接受5-氟尿嘧啶（5-Fu ）及其衍生物为基础的辅助化疗4～6 个周期，免 疫组化检测PinX1 蛋白的表达，并分析其与临床病理特征及预后的关系，率的分析采取卡方检验， 生存分析应用Kaplan-Meier 法和Cox 风险比例模型。结果 36 例（43.4% ）癌组织的PinX1 蛋白呈 低表达，而在相应癌旁组织中，仅 8 例（9.6% ）呈低表达，差异有统计学意义（P ＜0.05 ）。尽管 PinX1 表达下调与临床病理参数无关，经生存分析和 Cox 风险比例回归模型显示，PinX1 表达下调 是OS 及DFS 的独立预后指标。结论 PinX1 表达下调在结直肠癌发生发展中起重要作用，并可能 成为5-Fu 辅助化疗结直肠癌患者预后判断指标。 【关键词】 免疫组织化学； 结直肠癌； 预后； PinX1 1 Expression of PinX1 protein in colorectal cancer and its clinical significance Jiao Nanlin , Deng 2 3 1 1 3 Wenying , Ye Xiaobing , Zhang Fan . Department of Pathology, Department of Medical Oncology, Yijishan Hospital, Wannan Medical College, Wuhu 241001, China; 2Department of Medical Oncology, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China Corresponding author: Zhang Fan, Email: zhangfanyjs@163.com 【Abstract 】 Objective To explore the expression of PinX1 protein in colorectal cancer (CRC) tissues and its clinical significance. Methods A total of 83 paired CRC specimens and their adjacent normal tissues were collected, all of the patients received 4-6 cycles of 5-fluorouracil (5-Fu) based adjuvant chemotherapy. PinX1 protein expression was analyzed by immunohistochemical staining, its correlations with clinicopathological factors and prognosis were further evaluated. Results PinX1 expression was decreased in 36 tumor tissues (43.4%), whi