PSMA6基因rs17458312位点多态性与脑梗死的相关性研究擎.pdfVIP

中国康复理论与实践2015年9月第21卷第9期 ChinJRehabilTheoryPract,Sep.,2015,Vol.21,No.9 - 1091 - DOI: 10.3969/j.issn. 1006-9771.2015.09.023 ·临床研究 · PSMA6 基因r位点多态性与脑梗死的相关性研究① 1 2 赵西耀 ，何芳梅 [摘要] 目的 探讨中国汉族人群中PSMA6 基因rs- 1520C/T)位点的多态性与脑梗死的相关性。方法 对211 例脑梗 死患者(病例组) 和201 例健康体检者(对照组) ，应用聚合酶链反应- 限制性片段长度多态性分析法(PCR-RFLP)检测PSMA6 基因 rs点单核苷酸多态性，并分析其基因型及等位基因频数的分布。结果 CC、CT、TT 基因型频率及C 等位基因频率在 两组中分布无显著性差异(P0.05) 。性别分层后，各亚组各基因型及等位基因频率分布也无显著性差异(P0.05) 。结论 PSMA6 基 因rs点可能与脑梗死的发病无关。 [关键词] PSMA6 基因；单核苷酸多态性；脑梗死 Association of rPolymorphism of PSMA6 Gene with Cerebral Infarction 1 2 ZHAO Xi-yao , HE Fang-mei 1. Department of Neurology, the Second Affiliated Hospital (Jiande Branch), School of Medicine, Zhejiang Univer- sity, Jiande, Zhejiang 311600, China; 2. Department of Neurology, the First Affiliated Hospital of Xian Medical Univer- sity, Xian, Shaanxi 710077, China Abstract: Objective To evaluate the association between rs(- 1520C/T) polymorphism of PSMA6 gene and cerebral infarc- tion in Chinese Han population. Methods 211 cerebral infarction patients (case group) and 201 healthy controls (control group) were select- ed in the study. The single nucleotide polymorphism of rof PSMA6 gene was identified with the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). The genotypes and allele frequencies distributed in cerebral infarction patients and healthy controls were analyzed. Results The frequencies of CC, CT, TT genotypes and the C allele all revealed no significant difference between th