定量检测N末端脑钠肽对心衰的诊断价值.pdfVIP

lab 30,No．1 23 垦睦垫堕垦字杂志2009年1月第30卷第1期IntJ Med—,January200—9,VoL ·论著· 定量检测N末端脑钠肽对心衰的诊断价值 汪隆海 张平 陈启松 【摘要】 目的 评价血清N末端脑钠肽(NT-proBNP)定量检测对心力衰竭患者的诊断价值。 方法采用定量El。ISA改进法检测不同心衰程度的患者血清NT—proBNP。结果心衰患者血清 NT—proBNP水平明显增高，并随心衰患者程度加重呈指数增加；实验受试者工作特征曲线下面积为 0．898；心衰的诊断敏感性和特异性分别为91．9oA和92．3％。结论定量检测血清NT—proBNP是目 前用于评价心衰患者的最佳实验手段。 【关键词】利钠肽，脑；心力衰竭，充血性；诊断 中图分类号：R446．61；R541．61文献标识码：A 文章编号：1673—4130(2009)01—0023—03 valueofN-terminalnatriuretic detectionin ofheart Theclinical pro-brain peptidequantitative diagnosis failureWANG ClinicalLaborato— Long—hall，ZHANGPin92，CHENQi—song3．1．Departmentof Ultrasonic ry；2．Roomof Diagnosis；3．DepartmentofCardiology，thePeople’sHospitalof Hanshan 238100，China County，Hanshan Toevaluatethe valueofN—terminal natriuretic [Abstract]0bjectivediagnostic pro-brain pep— detectionin withheartfailure．Methods tide(NT—proBNP)quantitativepatients Quantitativeenzyme- linkedimmunosorbent methodwas to serumlevelof assay(ELISA)improvementappliedmeasuring in withdifferentofheartfailure．ResultsTheserumlevelof patients degree NT—proBNP NT-proBNP elevatedin withheart theincreaseofextentofheart was failure．With failure， significantly patients increasedin characteristiccurve(ROC)showedthatareaun— NT—proBNP exponent．Receiveroperator dercurve(AUC)was0．898．The and were91．9％and for sensitivityspecificity 92．3％respectively ofheartfailure．Conclusiondetectionof isat thebestla- diagnosis Quantitative NT—proBNPpresent testfor heartfunctionof wi