血尿酸和脂蛋白a水平与冠状动脉病变程度的关系.docVIP

血尿酸和脂蛋白-a水平与冠状动脉病变程度的关系 　　作者：李屏， 熊晓昉 作者单位：贵阳医学院附院 心内科， 贵州 贵阳 550004 　　【摘要】 目的： 探讨血尿酸(SUA)和脂蛋白-a[Lp(a)]水平与冠状动脉病变严重程度的相关性。方法： 224例患者根据选择性冠状动脉造影(CAG)结果分为冠心病组121例，正常对照组103例，再根据Gensini评分系统将冠心病组分为2组，其中Gensini积分30分66例为冠心病A组，Gensini积分≥30分55例为冠心病B组;再根据冠状动脉病变支数分为单支病变组46例，双支病变组46例，多支病变组29例。分别测定其SUA和Lp(a)水平，并分析二者与冠心病冠脉病变严重程度的相关性。结果： 冠心病组SUA和Lp(a)水平明显高于正常对照组(P0.05)，冠心病B组SUA和Lp(a)的水平明显高于冠心病A组(P0.05)，双支病变组和多支病变组之间比较冠脉病变支数越多，SUA和Lp(a)水平就越高(P0.05)，单支病变组与对照组比较SUA和Lp(a)的水平差异无统计学意义( P0.05)。SUA与Gensini积分相关系数为0.451，Lp(a)与Gensini积分相关系数为0.413。 结论： 动脉粥样硬化(AS)患者SUA和Lp(a)的水平高低与冠状动脉病变严重程度呈明显正相关。 　　【关键词】 脂蛋白(A); 冠状动脉疾病; 冠状血管造影术; 血尿酸 　　A Research on the Relationship of Blood Uric Acid and Lipoprotein-a 　　Level with the Pathological Condition of Coronary Artery 　　LI Ping, XIONG Xiaofang 　　(Department of Cardiovascular Medicine， The Affiliated Hospital of Guiyang Medical College， Guiyang 550004， Guizhou, China) 　　[Abstract] Objective: To investigate the relationship of serum uric acid (SUA) and lipoprotion-a (LP-a) with the pathological condition of coronary artery. Methods: According to coronary angiography, two hundred and twenty-four patients were divided into two groups: The coronary heart disease (CHD) group (n=121) and non-CHD group (control group) (n=103). The CHD group was further divided into two subgroups according to accumulated points of Gensini scoring system: patients with Gensini score 30 were in group A (n=66), and those with Gensini score ≥30 in group B (n=55). The CHD group was also further divided into three subgroups according to the number of diseased vessels: one diseased vessel group ( group 1,n= 46), two diseased vessel group (group 2,n=46), and three diseased vessel group (group 3,n=29). The levels of SUA and LP-a were measured, and the relationship of them with the pathological severity of coronary artery was analyzed.Results: The levels of SUA and LP-a in group CHD were significantly higher than those of control group (P0.05). The levels of S