Effects+of+total+saponins+of+Panax+notoginseng+on+immature+neuroblasts+in+the+adult+olfactory+bulb+following+global+cerebral+ischemia-reperfusion.pdf

NEURAL REGENERATION RESEARCH September 2015,Volume 10,Issue 9 RESEARCH ARTICLE Effects of total saponins of Panax notoginseng on immature neuroblasts in the adult olfactory bulb following global cerebral ischemia/reperfusion 1, 2, # 3, # 4 1 1, * 1, * Xu He , Feng-jun Deng , Jin-wen Ge , Xiao-xin Yan , Ai-hua Pan , Zhi-yuan Li 1 Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, Hunan Province, China 2 Department of Anatomy, Yiyang Medical College, Yiyang, Hunan Province, China 3 Department of Pharmacy, Yiyang Medical College, Yiyang, Hunan Province, China 4 Department of Integrated Traditional and Western Medicine, Hunan University of Traditional Chinese Medicine, Changsha, Hunan Province, China Abstract *Correspondence to: The main active components extracted from Panax notoginseng are total saponins. They have Ai-hua Pan, Ph.D. or Zhi-yuan Li, Ph.D., been shown to inhibit platelet aggregation, increase cerebral blood flow, improve neurological panaihua@ or behavior, decrease infarct volume and promote proliferation and differentiation of neural stem li_zhiyuan@. cells in the hippocampus and lateral ventricles. However, there is a lack of studies on whether total saponins of Panax notoginseng have potential benefits on immature neuroblasts in the # These authors contributed equally to olfactory bulb following ischemia and reperfusion. This study established a rat model of global this work. ce