Fluoride+Exposure,+Follicle+Stimulating+Hormone+Receptor+Gene+Polymorphism+and+Hypothalamus-pituitary-ovarian+Axis+Hormones+in+Chinese+Women.pdf

Fluoride+Exposure,+Follicle+Stimulating+Hormone+Receptor+Gene+Polymorphism+and+Hypothalamus-pituitary-ovarian+Axis+Hormones+in+Chinese+Women.pdf

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Fluoride+Exposure,+Follicle+Stimulating+Hormone+Receptor+Gene+Polymorphism+and+Hypothalamus-pituitary-ovarian+Axis+Hormones+in+Chinese+Women.pdf

696 Biomed Environ Sci, 2015; 28(9): 696-700 Letter to the Editor Fluoride Exposure, Follicle Stimulating Hormone Receptor Gene Polymorphism and Hypothalamus-pituitary-ovarian Axis Hormones in Chinese Women* 1,△ 1,△ 1 2 1 ZHAO Ming Xu , ZHOU Guo Yu , ZHU Jing Yuan , GONG Biao , HOU Jia Xiang , 1 1 2 1 1,# ZHOU Tong , DUAN Li Ju , DING Zhong , CUI Liu Xin , and BA Yue The effects of fluoride exposure on the results were also inconsistent. functions of reproductive and endocrine systems It is possible that genetic changes, such as single have attracted widespread attention in academic nucleotide polymorphisms (SNPs), either by circle nowadays. However, it is unclear whether the themselves or in combination, modify and finetune gene-environment interaction may modify the endocrine-feedback systems and hormone action[3]. secretion and activity of hypothalamus-pituitary- The FSH receptor (FSHR) belongs to the superfamily ovarian (HPO) axis hormones. Thus, the aim of this of G-protein coupled receptors coded by the FSHR study was to explore the influence of fluoride gene (chr 2p21) and plays a crucial role in the exposure and follicle stimulating hormone receptor physiology of human reproductive system. Mutation (FSHR) gene polymorphism on

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