Hyperbaric+oxygen+therapy+combined+with+Schwann+cell+transplantation+promotes+spinal+cord+injury+recover+y.pdf

NEURAL REGENERATION RESEARCH September 2015,Volume 10,Issue 9 RESEARCH ARTICLE Hyperbaric oxygen therapy combined with Schwann cell transplantation promotes spinal cord injury recovery 1 2 1 1 1 3 1, * Chuan-gang Peng , Shu-quan Zhang , Min-fei Wu , Yang Lv , Dan-kai Wu , Qi Yang , Rui Gu 1 Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China 2 Department of Orthopedics, Tianjin Nankai Hospital, Tianjin, China 3 Department of Dynaecology and Obstetrics, China-Japan Union Hosptial of Jilin University, Changchun, Jilin Province, China Abstract *Correspondence to: Schwann cell transplantation and hyperbaric oxygen therapy each promote recovery from spinal Rui Gu, M.D., fandiliuel@126.com. cord injury, but it remains unclear whether their combination improves therapeutic results more than monotherapy. To investigate this, we used Schwann cell transplantation via the tail vein, orcid: hyperbaric oxygen therapy, or their combination, in rat models of spinal cord contusion injury. 0000-0003-4406-1553 (Rui Gu) The combined treatment was more effective in improving hindlimb motor function than either treatment alone; injured spinal tissue showed a greater number of neurite-like structures in the doi: 10.4103/1673-5374.165520 injured spinal tissue, somatosensory and motor evoked potential latencies were notably shorter, / and their amplitudes greater, after combination therapy