Modiifcation+of+tenascin-R+expression+following+unilateral+labyrinthectomy+in+rats+indicates+its+possible+role+in+neural+plasticity+of+the+vestibular+neural+circuit.pdf

NEURAL REGENERATION RESEARCH September 2015,Volume 10,Issue 9 RESEARCH ARTICLE Modification of tenascin-R expression following unilateral labyrinthectomy in rats indicates its possible role in neural plasticity of the vestibular neural circuit 1 1 1 2 1 1, 3, * Botond Gaal , Einar Örn Jóhannesson , Amit Dattani , Agnes Magyar , Ildikó Wéber , Clara Matesz 1 Department of Anatomy, Histology and Embryology, Faculty of Medicine and Faculty of Dentistry, University of Debrecen, Nagyerdei krt. 98, Debrecen, Hungary 2 Department of Pediatric Surgery, Faculty of Medicine, Clinical Center, University of Debrecen, Nagyerdei krt. 98, Debrecen, Hungary 3 MTA-DE Neuroscience Research Group, University of Debrecen, Nagyerdei krt. 98, Debrecen, Hungary Abstract *Correspondence to: We have previously found that unilateral labyrinthectomy is accompanied by modification of Clara Matesz, M.D., Ph.D., hyaluronan and chondroitin sulfate proteoglycan staining in the lateral vestibular nucleus of matesz@anat.med.unideb.hu. rats and the time course of subsequent reorganization of extracellular matrix assembly cor- relates to the restoration of impaired vestibular function. The tenascin-R has repelling effect on orcid: pathfinding during axonal growth/regrowth, and thus inhibits neural circuit repair. By using 0000-0002-3091-0756 (Clara Matesz) immunohistochemical method, we studied the modification of tenascin-R expression in the