Ultrasensitive+detection+of+DNA+and+protein+markers+in+cancer+cells.pdfVIP

Cancer Biol Med 2015;12:143-149. doi: 10.7497/j.issn.2095-3941.2015.0048 REVIEW Ultrasensitive detection of DNA and protein markers in cancer cells Irina V. Smolina, Natalia E. Broude Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA ABSTRACT Cancer cells differ from normal cells in various parameters, and these differences are caused by genomic mutations and consequential altered gene expression. The genetic and functional heterogeneity of tumor cells is a major challenge in cancer