Effect of resveratrol on proliferation and differentiation of embryonic cardiomyoblasts》.pdfVIP

Effect of resveratrol on proliferation and differentiation of embryonic cardiomyoblasts》.pdf

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Effect of resveratrol on proliferation and differentiation of embryonic cardiomyoblasts》.pdf

Biochemical and Biophysical Research Communications 360 (2007) 173–180 /locate/ybbrc Effect of resveratrol on proliferation and differentiation of embryonic cardiomyoblasts Chi-Weng Leong a, Chi Hang Wong b, Sin-Cheng Lao a, Emilia Conceic¸ao Leong a, ˜ Iok Fong Lao a, Patrick Tik Wan Law b, Kwok Pui Fung b,c, Kam Sze Tsang d, Mary Miu-Yee Waye b, Stephen Kwok-Wing Tsui b, Yi-Tao Wang a,*, Simon Ming-Yuen Lee a,c,* a Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao, China b Department of Biochemistry, The Chinese University of Hong Kong, Hong Kong, China c Institute of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, China d Department of Anatomical Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, China Received 2 June 2007 Available online 12 June 2007 Abstract Resveratrol (trans-3,5,40 -trihydroxystilbene), a polyphenolic compound found largely in the skins of red grapes, has been used as a nutritional supplement or an investigational new drug for prevention of cardiovascular diseases. Previous reports showed that resveratrol had a protective effect against oxidative agent-induced cell injury. Our studies indicate that resveratrol plays a role in the differentiation of cardiomyoblasts. The cardiomyoblast cell line, H9c2, w

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