Establishment of a humanized model of liver using NODShi-scid IL2Rgnull mice》.pdfVIP

Biochemical and Biophysical Research Communications 377 (2008) 248–252 Contents lists available at ScienceDirect Biochemical and Biophysical Research Communications journal homepage: www.else /loc ate/ybbrc Establishment of a humanized model of liver using NOD/Shi-scid IL2Rgnull mice Hiroshi Suemizu a,*,1, Masami Hasegawa a,d,1, Kenji Kawai b, Kenji Taniguchi a,d, Makoto Monnai a,e, Masatoshi Wakui b,f f c g,2 b,h , Makoto Suematsu , Mamoru Ito , Gary Peltz , Masato Nakamura a Biomedical Research Department, Central Institute for Experimental Animals, 1430 Nogawa, Miyamae, Kawasaki, Kanagawa 216-0001, Japan b Pathology Research Department, Central Institute for Experimental Animals, 1430 Nogawa, Miyamae, Kawasaki, Kanagawa 216-0001, Japan c Laboratory Animals Research Department, Central Institute for Experimental Animals, 1430 Nogawa, Miyamae, Kawasaki, Kanagawa 216-0001, Japan d Pharmaceutical Research Department II, Chugai Pharmaceutical Co., Ltd., 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan e Chugai Research Institute for Medical Science, Inc., 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan f Department of Biochemistry and Integrative Medical Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan g Department of Genetics and Genomics, Roche Palo Alto, 3431 Hillview Avenue, Palo Alto, CA 94304-1397, USA h Department of Pathology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan a r t i c l e i n f o a b s t r a c t Article history: