High density lipoprotein, apoproteins A-I and A-II and postheparin plasma lipolytic enzymes after ileal bypass》.pdfVIP

At/rrro.\ck~ro.srs, 63 (19X7) 181-1X6 181 Elsevier Scientific Publishers Ireland, Ltd ATH 03867 High density lipoprotein, apoproteins A-I and A-II and postheparin plasma lipolytic enzymes after ileal bypass Pekka Koivisto, ’ Timo Kuusi * and Tatu A. Miettinen ’ ’ Src,ond md ’ Third Depurrmenrs of Medime. Utuwrsrt~ of Hrlsmkr, SF-00290 Ilelsrr~h~ (F~nimd/ (Received 29 May. 19X6) (Revised. received 24 July, 1986) (Accepted 1XAugust, 19X6) Summary Apoproteins A-I and A-II, and the activities of lipoprotein lipase (LPL) and hepatic lipase (HL), were studied in 16 patients 3-12 years after ileal bypass operation and in 13 controls, all heterozygous for familial hypercholesterolemia, to investigate why the operated subjects had a higher HDL cholesterol level than the unoperated controls. HDL- and HDL,-cholesterol and apoprotein A-I were higher, HDL,-cholesterol was similar and apoprotein A-II tended to be lower in the operated than the control subjects. The activities of LPL and HL were similar in the 2 groups. HL was negatively correlated with HDL,-cholesterol, whereas LPL was not associ