Human apolipoprotein A–I binds amyloid-β and prevents Aβ-induced neurotoxicity》.pdfVIP

The International Journal of Biochemistry Cell Biology 41 (2009) 1361–1370 Contents lists available at ScienceDirect The International Journal of Biochemistry Cell Biology j o u rn al h omepage: w w w. elsev /locate/biocel Human apolipoprotein A–I binds amyloid- and prevents A-induced neurotoxicity Andréa C. Paula-Lima a,1, M. Alejandra Tricerri c,1, Jordano Brito-Moreira a , Theresa R. Bomfim a , Fabio F. Oliveira a , Margaret H. Magdesian a , Lea T. Grinberg d , Rogerio Panizzutti b , Sérgio T. Ferreira a,∗ a Programa de Bioquímica e Biofísica Celular, Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-590, Brazil b Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil c Instituto de Investigaciones Bioquímicas de La Plata, Universidad Nacional de La Plata, La Plata, Argentina d Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil a r t i c l e i n f o a b s t r a c t Article history: Aggregates of the amyloid- peptide (A) play a central role in the pathogenesis of Alzheimer’s disease Received 7 August 2008 (AD). Identification of proteins that physiologically bind A and modulate its aggregation and neurotox- Received in revised form icity could lead to the development of novel disease-modifying approaches in AD. By screening a phage 27 November 2008 display peptide library for high affinity ligands of aggregated A1–42, we isolated a peptide homologous Accept