Probe-based chemical modulations of tissues for IMS》.pdf

J O U R N A L O F P R O T E O M I C S 7 5 ( 2 0 1 2 ) 4 9 2 1 – 4 9 3 0 A v a i l a b l e o n l i n e a t w w w . s c i e n c e d i r e c t . c o m w w w . e l s e v i e r . c o m / l o c a t e / j p r o t Review Probe-based chemical modulations of tissues for IMS☆ H.M. Santosa, b, c,⁎, J.L. Capeloa, d aREQUIMTE, Departamento de Química, Centro de Química Fina e Biotecnologia (CQFB), Faculdade de Ciências e Tecnologia (FCT), Universidade NOVA de Lisboa (UNL), Campus de Caparica, 2829‐516 Caparica, Portugal bInstitute for Biotechnology and Bioengineering (IBB), Centre for Genomics and Biotechnology (CGB), University of Trás-os-Montes and Alto Douro, 5001‐801 Vila Real, Portugal cInstitute for Biotechnology and Biomedicine (IBB), University Autónoma of Barcelona (UAB), 08193 Bellaterra, Spain dPhysical Chemistry Department, Science Faculty, University of Vigo at Ourense Campus, E-32004 Ourense, Spain A R T I C L E I N F O A B S T R A C T Article history: Chemical modulation imaging over a tissue is gaining momentum in the field of mass Received 20 March 2012 spectrometry. Some endogenous or exogenous compounds present in a tissue can be Accepted 17 May 2012 visualized by imaging mass spectrometry after chemical derivatization. This approach gives Available online 25 May 2012 researchers the possibility to elude chemical interferences in components of the tissues, such as lipids or salts, as well