Procedure for developing linear and Bayesian classification models based on immunosensor measurements》.pdfVIP

Sensors and Actuators B 190 (2014) 165–170 Contents lists available at ScienceDirect Sensors and Actuators B: Chemical j o u rn al h o m e p ag e: w w w. elsev /locat e / s n b Procedure for developing linear and Bayesian classification models based on immunosensor measurements Stephen Mobley a,∗ , Sunil Yalamanchili a , Hongzheng Zhang b , Rossella Marullo b , Zhuo G. Chen b , Carlos S. Moreno c , Dong M. Shin b , Paul W. Doetsch b , William D. Hunt a a School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA b Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA c Department of Pathology Laboratory Medicine, Whitehead Research Building of Emory University, Atlanta, GA 30322, USA a r t i c l e i n f o a b s t r a c t Article history: A protocol for the creation of a set of classification models was developed to differentiate between biolog- Received 15 May 2013 ical samples based on immunosensor measurements. For this paper, data was gathered using Au Quartz Received in revised form 23 August 2013 Crystal Microbalance with Dissipation (QCM-D) sensors inoculated with an alkanethiol self-assembling Accepted 28 August 2013 monolayer functionalized for the detection of pAkt, H2AX, -Actin, and FITC antigen expression. Available online 5 September 2013 Oropharyngeal cancer lysate samples, both positive (SCC47) and negative (TU212) for high risk human