Promoting neurogenesis via Wntβ-catenin signaling pathway accounts for the neurorestorative effects of morroniside against cerebral ischemia injury》.pdf

European Journal of Pharmacology 738 (2014) 214–221 Contents lists available at ScienceDirect European Journal of Pharmacology journal homepage: /locate/ejphar Neuropharmacology and analgesia Promoting neurogenesis via Wnt/β-catenin signaling pathway accounts for the neurorestorative effects of morroniside against cerebral ischemia injury Fang-Ling Sun a, Wen Wang a,n, Wei Zuo a, Jin-Long Xue a, Jing-dong Xu b, Hou-Xi Ai a, Li Zhang a, Xiao-Min Wang c,nn, Xun-Ming Ji d,nnn a Department of Pharmacology, Xuanwu Hospital of Capital Medical University, 45 Chang-chun Street, Beijing 100053, China b Department of Physiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China c Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men Beijing 100069, China d Department of Neurosurgery, Xuanwu Hospital of Capital Medical University, 45 Chang-chun Street, Beijing 100053, China a r t i c l e i n f o a b s t r a c t Article history: Ischemic stroke is a leading cause of mortality and permanent disability in adults worldwide. Neuro- Received 25 October 2013 genesis triggered by ischemia in the adult mammalian brain may provide insights into stroke treatment. Received in revised form Morroniside is an active component of sarcocarp of C. offi cinalis that have shown neuroprotective effects. 4 May 2014 The aim of the present study is to test whether morroniside promotes neurogenesis via Wnt/β-catenin Accepted 10 May 2014