Proteomic and bioinformatic analyses of possible target-related proteins of gambogic acid in human breast carcinoma MDA-MB-231 cells》.pdf

Chinese Journal of Natural Chinese Journal of Natural Medicines 2015, 13(1): 0041−0051 Medicines Proteomic and bioinformatic analyses of possible target- related proteins of gambogic acid in human breast carcinoma MDA-MB-231 cells 1, 2 2, 3 † 2, 3 3 2 2 LI Dong , SONG Xiao-Yi , Yue Qing-Xi , CUI Ya-Jun , LIU Miao , FENG Li-Xing , WU Wan-Ying2 2 2 1* 2* 2 , JIANG Bao-Hong , YANG Min , QU Xiao-Bo , LIU Xuan , GUO De-An 1Changchun University of Chinese Medicine, Changchun 130117, China; 2Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; 3Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China Available online 20 Jan. 2015 [ABSTRACT] Gambogic acid (GA) is an anticancer agent in phase Ⅱb clinical trial in China but its mechanism of action has not been fully clarified. The present study was designed to search the possible target-related proteins of GA in cancer cells using proteomic method and establish possible network using bioinformatic analysis. Cytotoxicity an