Radiation induced oxidative stress and its toxicity in testes of mice and their prevention by Tinospora cordifolia extract》.pdf

j o u r n a l o f r e p r o d u c t i v e h e a l t h a n d m e d i c i n e 1 ( 2 0 1 5 ) 6 4 – 7 5 Available online at ScienceDirect journal homepage: /locate/jrhm Original Article Radiation induced oxidative stress and its toxicity in testes of mice and their prevention by Tinospora cordifolia extract Priyanka Sharma a, Jyoti Parmar a, Preeti Verma a, P.K. Goyal b,* a Radiation Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302 004, India b Prof. and Head of the Department, Radiation Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302 004, India a r t i c l e i n f o a b s t r a c t Article history: Background: Reproductive dysfunctions induced by various environmental toxicants are the Received 21 July 2014 prime concern in the todays changing global scenario. Living systems are constantly Accepted 23 January 2015 exposed to ionizing radiation that cause cellular as well as genetic alterations leading Available online 7 February 2015 to mutations and cell death. To evaluate the deleterious effects of low dose of gamma radiation on testicular tissue and their possible inhibition by Tinospora cordifolia root Keywords: extract (TCE). Gamma radiation Methods: One group of Swiss albino mice was exposed to 2.5 Gy gamma radiation to serve as Radioprotection the irradiated control, while the other group received TCE (75 mg/kg b. wt./day) or