Rational design of shear-thinning supramolecular hydrogels with porphyrin for controlled chemotherapeutics release and photodynamic therapy》.pdf

European Polymer Journal 66 (2015) 149–159 Contents lists available at ScienceDirect European Polymer Journal journal homepage: www.elsevi /locate/europolj Rational design of shear-thinning supramolecular hydrogels with porphyrin for controlled chemotherapeutics release and photodynamic therapy Hua Jin a, Xiao-Hui Dai a,b,⇑, Chuan Wu a, Jian-Ming Pan a,⇑, Xiao-Hong Wang a, Yong-Sheng Yan a,b, Dong-Ming Liu c, Lin Sun d a Department of Chemical Engineering, School of Chemistry and Chemical Technology, Jiangsu University, Zhenjiang 212013, PR China b State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, PR China c Hospital Affiliated to Jiangsu University, Zhenjiang 212013, PR China d CSR Qingdao Sifang Co. Ltd., Qingdao, Shandong 266111, PR China a r t i c l e i n f o a b s t r a c t Article history: An amphiphilic porphyrin-cored, star-shaped poly (e-caprolactone)-b-poly (ethylene gly- Received 24 December 2014 col) (SPPCL-b-PEG) copolymer was synthesized and used as a building block for construct- Received in revised form 24 January 2015 ing supramolecular hydrogels. With the aid of a-cyclodextrin (a-CD), thixotropic and Accepted 29 January 2015 reversible supramolecular hydrogel could be formed by copolymers based on the host– Available online 13 February 2015 guest inclusion complexation (IC). Due to the biodegradable and biocompatible properties, this IC-based supramolecular hydrogel was used as carrier for doxorubicin (DOX)