原创力文档Ramucirumab versus placebo as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib (REACH) a randomised, double-blind, multicentre, phase 3 trial》.pdf
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Ramucirumab versus placebo as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib (REACH) a randomised, double-blind, multicentre, phase 3 trial》.pdf
Articles
Ramucirumab versus placebo as second-line treatment in
patients with advanced hepatocellular carcinoma following
fi rst-line therapy with sorafenib (REACH): a randomised,
double-blind, multicentre, phase 3 trial
Andrew X Zhu, Joon Oh Park, Baek-Yeol Ryoo, Chia-Jui Yen, Ronnie Poon, Davide Pastorelli, Jean-Frederic Blanc, Hyun Cheol Chung, Ari D Baron,
Tulio Eduardo Flesch Pfi ff er, Takuji Okusaka, Katerina Kubackova, Jorg Trojan, Javier Sastre, Ian Chau, Shao-Chun Chang, Paolo B Abada,
Ling Yang, Jonathan D Schwartz, Masatoshi Kudo, for the REACH Trial Investigators*
Summary
Background VEGF and VEGF receptor-2-mediated angiogenesis contribute to hepatocellular carcinoma pathogenesis. Lancet Oncol 2015; 16: 859–70
Ramucirumab is a recombinant IgG1 monoclonal antibody and VEGF receptor-2 antagonist. We aimed to assess the Published Online
safety and efficacy of ramucirumab in advanced hepatocellular carcinoma following fi rst-line therapy with sorafenib. June 19, 2015
/10.1016/
S1470-2045(15)00050-9
Methods In this randomised, placebo-controlled, double-blind, multicentre, phase 3 trial (REACH), patients were
See Comment page 751
enrolled from 154 centres in 27 countries. Eligible patients were aged 18 years or older, had hepatocellular carcinoma
with Barcelona Clinic Liver Cancer stage C diseas
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