Radiation induced heart disease Pathogenesis, management and review literature》.pdf

Journal of the Egyptian National Cancer Institute (2015) xxx, xxx–xxx Cairo University Journal of the Egyptian National Cancer Institute /locate/jnci Review Radiation induced heart disease: Pathogenesis, management and review literature R. Madan *, R. Benson, D.N. Sharma, P.K. Julka, G.K. Rath Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi 110029, India Received 28 May 2015; revised 23 July 2015; accepted 27 July 2015 KEYWORDS Abstract Radiation therapy (RT) is a very important part of multimodality cancer therapy. Radiation induced heart dis- Addition of RT improves survival in many cancers, but there are some accompaniments of radia- ease; tion. One of them is radiation induced heart disease (RIHD). RT for mediastinal lymphoma, breast, Pathogenesis; lung and oesophageal cancer is associated with the development of RIHD. The problem can be Treatment intensified with the addition of chemotherapy. Therapeutic modalities for RIHD are the same as in the non-irradiated population. However, surgery may be difficult in the irradiated patients. The long latent period is the reason why RIHD is not extensively studied. Survival of cancer patients has improved over past few decades, so RIHD is a growing concern especially in younger patients. In this review article, we have dis