Reduced In Vitro Clot Lysis and Release of More Active Platelet PAI-1 in Polycythemia Vera and Essential Thrombocythemia》.pdf

Thrombosis Research 90 (1998) 51–56 REGULAR ARTICLE Reduced In Vitro Clot Lysis and Release of More Active Platelet PAI-1 in Polycythemia Vera and Essential Thrombocythemia ″ ´ ´ ´ ´ ´ ´ ´ Emoke Posan, Gyorgy Ujj, Attila Kiss, Bela Telek, Kalman Rak and Miklos Udvardy ¨ 2nd Department of Medicine, University Medical School, Debrecen, Hungary. (Received 11 July 1997 by Editor H. Sinzinger; revised/accepted 10 November 1997) Abstract caused by higher plasmatic PAI-1 activity as well as by more active platelet PAI-1. The PAI-1 activ- Because platelets interact with fibrinolysis in a ity was significantly higher in the supernatants of complex manner, it can be expected that with ab- the washed and gel-filtered platelets of PV after normal platelet numbers and quality this interfer- activation by thrombin compared with controls. ence can be even more profound. The aim of this Other factors might have influenced the reduced work was to study the lysis-resistance of platelet- fibrinolysis.  1998 Elsevier Science Ltd. rich clots in diseases with high platelet counts: poly- Key Words: Fibrinolysis; Platelet-rich thrombus; Polycy- cythemia vera (PV), essential thrombocythemia themia vera; Essential thrombocythemia (ET) and to make comparison with polyglobulia (PG). Platelet-rich plasma (PRP) and platelet-poor hromboembolism is one of the most frequent plasma (PPP) were analyzed by an in vitro clot (20%–40%) and at the same time severely lysis test. Plasminogen activator inhibitor-1 (PAI- Torgan-damaging, ofte