Relation of Change in Apolipoprotein BApolipoprotein A-I Ratio to Coronary Plaque Regression After Pravastatin Treatment in Patients With Coronary Artery Disease》.pdf
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Relation of Change in Apolipoprotein BApolipoprotein A-I Ratio to Coronary Plaque Regression After Pravastatin Treatment in Patients With Coronary Artery Disease》.pdf
Relation of Change in Apolipoprotein B/Apolipoprotein A-I Ratio
to Coronary Plaque Regression After Pravastatin Treatment in
Patients With Coronary Artery Disease
Shigemasa Tani, MDa,b,*, Ken Nagao, MDa,b, Takeo Anazawa, MDa,b, Hirofumi Kawamata, MDa,b,
Shingo Furuya, MDa,b, Hiroshi Takahashi, MDa,b, Kiyoshi Iidaa,b, Michiaki Matsumoto, MDa,b,
Takehiko Washioa,b, Narimichi Kumabe, MDa,b, and Atsushi Hirayama, MDb
Some investigations have looked into the ability of measurements of apolipoprotein B/apo-
lipoprotein A-I (apoB/apoA-I) ratio to predict cardiovascular events. We hypothesized that
a decrease in the apoB/apoA-1 ratio by statin therapy would act on suppression of coronary
plaque progression. A 6-month prospective study was conducted of 64 patients with
coronary artery disease treated with pravastatin. The plaque volume, assessed by volumet-
ric intravascular ultrasonography, had decreased significantly by 12.6% (p 0.0001 vs
baseline). Although a significant decrease of 6.4% and 14.6% was found in the serum level
of apoB and the apoB/apoA-1 ratio (p 0.0001 and p 0.0001, respectively, vs baseline),
a significant increase of 14.0% of and 12.0% in the level of apoA-I and apoA-II (both
p 0.0001 vs baseline). No significant changes were found in the level of apoC-II or apoE.
A stepwise regression analysis revealed that the change in the apoB/apoA-1 ratio was an
independent predictor of the change in coronary plaque volume ( coefficient 0.386; p
0.0023). In conclusion, our results have indicated that the decrease in the apoB/apoA-I ratio
is a simple predictor for coronary at
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