再程立体定向放射治疗的应用.pdfVIP

国际医学放射学杂志 ： Ｉｎｔ Ｊ Ｍｅｄ Ｒａｄｉｏｌ ２０ 15 Sep鸦 ３8穴5雪 442-445 放射治疗学 再程立体定向放射治疗的应用 * 王境生 李丰彤 董 洋 庄洪卿 宋勇春 袁智勇 【摘要】 肿瘤经放射治疗或者多种方法联合治疗后， 局部复发经常出现， 但局部再程放疗仅适用于少数病 人，因其会引起潜在的严重并发症，特别是对大体积的肿瘤进行再程放疗时。 采用立体定向放射治疗（SBRT ）对复 发的椎体转移瘤、头颈部肿瘤、盆腔肿瘤进行再程放疗，不仅能够提高局部控制率并减轻症状，同时还能够减少正 常组织不良反应。 SBRT 在临床上是一种安全有效的方法，建议将 SBRT 作为控制局部症状的重要治疗手段。 【关键词】 肿瘤复发；立体定向放射治疗；再程放疗；局部控制率；正常组织耐受量；不良反应 DOI: 10.3874/j.issn.1674-1897.2015.05.Z0507 Application of re -course stereotactic radiotherapy WANG Jingsheng, LI Fengtong, DONG Yang, ZHUANG Hongqing, SONG Yongchun, YUAN Zhiyong. Department of Radiation Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of cancer Prevention and Therapy, Tianjin 300060, China 【Abstract 】 After radiation therapy or combination therapy, local tumor recurrence appears frequently.However, only few patients are suitable for partial re-radiotheraphy, becasue it may cause potentially serious complications, especially in large volume tumor re-radiotheraphy. With stereotactic body radiation therapy （ＳＢＲＴ ）, we can improve local control rate, relieve symptoms and reduce normal tissues adverse reaction for recurrence of vertebral metastases, head and neck tumors, and pelvic tumors. SBRT is a safe and effective treatment, and is recommended as an important control local symptoms treatment. 【Key words 】 Local recurrence; Stereotactic radiotherapy; Re-irradiation; Local control rate; Normal tissue tolerance; Toxic adverse reaction