1上市后药品安全性研究--詹思延教授.ppt

眼葡萄膜炎与利福布丁 network meta-analysis mixed treatment comparison multiple treatments meta-analysis 本文观看结束！！！ * The possible environmental and genetic factors of ATLI have always been the matter of concern. It is well documented that the risk of ADR increases with age, malnutrition, and history of hepatitis. In addition, a large number of other environmental factors have been hypothesized to be associated with ADRs such as HIV and hepatitis C virus infection. But questions remain about the effects of these exposures. Genetic factors like isoniazid-metablising enzyme gene polymorphisms were studied a lot but these studies also showed inconsistent results. Until now, the comprehensive study for environmental, genetic, clinical and administrative factors has not been reported. * * * Research question Literature review Search strategy Collection papers Inclusion exclusion criteria (in/out from) Data collection form Quality standard At least two independent researchers’ opinions Quantitative synthesis Heterogeneity exploration Reporting writing Peer review of the report Therefore, getting an overview of those clinical, economical and public health impacts for TB patients and TB control will be quite meaningful. The ADACS is a prospective longitudinal study of anti-tuberculosis drugs induced adverse reactions based on a multi-center cohort of 4488 pulmonary tuberculosis patients receiving China National Tuberculosis Prevention and Control Scheme treatment. Firstly, participants recruited would finish the baseline questionnaire and receive several physical and laboratory examinations, including weight, height measurement, blood, urine routine test, liver, renal function test and hepatitis B surface antigen (HBsAg) test. All tests were done in local CDC laboratory using uniform reagents and equipments corrected with standard sample from National CDC lab. A drop of intravenous blood for each patient from the laboratory examination blood sampling was taken and saved in Wha