脂噬对脂类代谢和慢性肝脏疾病影响的研究进展.pdfVIP

·综述· 脂噬对脂类代谢和慢性肝脏疾病影响的研究进展 周峰关秀茹 【摘要】最新研究发现了一种新的选择性自噬——脂噬，其可以选择性识别脂质并将其降解，在 调节肝细胞脂肪代谢、维持细胞内脂质稳态等过程中发挥重要作用。自噬参与肝细胞的多种功能，不仅 可以动员脂滴，调控脂肪的分解代谢，还参与极低密度脂蛋白(VLDL)的分泌和装载。但高脂饮食、饮酒 和肝炎病毒会破坏自噬功能，使肝细胞发生脂肪样变、纤维化或凋亡，进一步发展成脂肪肝、酒精肝，甚 至肝癌。因而研究脂噬对脂质代谢的调节作用，脂噬对病毒性肝炎和脂肪肝等慢性肝脏疾病的影响很 有意义。 【关键词】脂噬；脂质代谢；脂肪肝；肝炎病毒 Theroleof in metabolismandchronic liverdiseases．Zhou lipophagylipid feng，Guan xiuru．Depart— ment Fimt Medical ofLaboratoryDiagnostics，TheAffiliatedHospitalofHarbin University，Harbin150001，China author：GUAN 1@163．com Corresponding xiuru，Email：gnanxiuru045 evidence anew ofselective selective． 【Abstract】Currentimplicatestype autophagy—lipophagy，which andbreaksdown essentialin metabolism 1yrecognizes lipids．Lipophagyplay rolesregulatinglipid andmaintai— cellular involvesinmulti—functionsinliver．It not mobilize ning lipidhomeostasis．Autophagy mightonly lipid to catabolismof butalsoinvolvesinthesecretionand of low dropletsregulate lipid assemblyvery densitylipo— functionsaredisordered or protein(VLDL)．However，autophagichigh—fatdiet，alcohol by consumptionhepati— tis insteatosisandfibrosiseven of furtherleadto conditions virus，resulting apoptosishepatocytes．Thesemay the of isessential developmentfattyliver，alcoholichepatitis，cirrhosis，andhepatocelluarcarcinoma(HCC)．It to rolesof metabolismandinfluencesinchromicliver． e