Secular trend analysis of lung cancer incidence in Sihui city, China between 1987 and 2011.pdfVIP
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Secular trend analysis of lung cancer incidence in Sihui city, China between 1987 and 2011.pdf
Dueta1.ChinJCancer2《015)34:33
DOI10.11861s40880—015一o037—3 ChineseJournaIofCancer
CrossMark
,_ i - i i · ●
ecuIartrenaanaIysIsotIUnqcancer
incidenceinSihuicity,Chinabetween1987
and2011
Jin~LinDu,,十XiaoLin十
, , Li-FangZhang ,Yan—HuaLi,Shang—HangXie,,Meng-JieYang,,JieGuo ,
Er-HongLin,QingLiu,,Ming—HuangHong’,,Qi—HongHuang,Zheng—ErLiao andSu—MeiCao’,
Abstract
Background:WithindustrialandeconomicdevelopmentinrecentdecadesinSouthChina,cancerincidencemay
havechangedduetothechanginglifestyleandenvironment.However,thetrendsoflungcancerandtherolesof
smokingandotherenvironmentalriskfactorsinthedevelopmentoflungcancerinruralareasofSouthChinaremain
unclear.Thepurposeofthisstudywastoexplorethelungcancerincidencetrendsandthepossiblecausesofthese
trends.
Methods:Joinpointregressionanalysisandtheage—period—cohort(APC)modelwereusedtoanalyzethelungcan—
cerincidencetrendsinSihui,Guangdongprovince,Chinabetween1987and2011,andexplorethepossiblecausesof
thesetrends.
Results:AtotaIof2.397lungcancerpatientswereinvolvedinthisstudy.A3-foIdincreaseintheincidenceoflung
cancerinbothsexeswasobservedoverthe25一yearperiod.Joinpointregressionanalysisshowedthatwhiletheinci—
dencecontinuedtoincreasesteadilyinfemalesduringtheentireperiod.asharpaccelerationwasobservedinmales
startingin2005.ThefuIlAPCmode1wasselectedtodescribeage,period.andbirthcohorteffectsonIungcancerinci—
dencetrendsinSihui.Theagecohortsinbothsexesshowedacontinuouslysignificantincreasejntherelativerisk(RR)
oflungcancer,withapeakfntheeldestagegroupf80—84years).TheRRoffungcancershowedafluctuatingcurvein
bothsexes.ThebirthcohortsidentifiedanincreasedtrendinbothmaIesandfemales;however,maleshadaplateau
intheyoungestcohortswhowereborndur
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