硫普罗宁金属药物的合成和结构确证.pdfVIP

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硫普罗宁金属药物的合成和结构确证.pdf

ABSTRACT isanew haSbeen usedin Tiopronin,N-(2一mercaptopmpionyl)glycinedmg,w“ch widely call and clinicasmemedicinefor liverf嘶ction.It improving comprehensiVelyemectiVely curethe vimala11dalcoholic thefhnctionjndexmarkaIld of improve symptom hepatitis,be takenas ofthe aIldthe andbeusedastIleantidote pmtectingagents mdiomer印ychemoⅡlcrapy of hasbeen is mentalorsome it discovered eaSily to heavy dnlgs.But tiopmnin decomposed clinicwhemerinbⅢfer oras a abIlIldallt in solutionsuch.Asresllltt11e produce byproducts aIldthe e虢ctwere madeane肺rtto productpur埘declinesec嘶哆and destroyed.So、Ⅳe tobemetalsalt. modi匆tioproIlin Aneralotof for andzmc experiments,we丘ndprocessespreparingpOtaSsillrntiopronin havetlle canbe tiopronin,w量lichhigheryields,bett甜pmducts,simpleroperation髓ds佃1ply into AndtheresIlltsofresearchindicatedthat put opera:tionindus砸ally andzinc to better tioprollin,comp捌ngtiopromn,havestabili毋 Inthe stnJctIlresof mealltime,t}le pOtassiumtiopronin甜ld西nctiopron曲areverined, deteHninationof aIldchemical throu曲the i招pHysicaJ constallts,o唱a11icanalysis,InnⅢed MaSs Spectmm(1R),Ul拄aⅥ01etSpectnun(uV),1H.NMR,13C.NMR aj X-rayDi珩action(Ⅺm),et Attlle

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