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- 约 67页
- 2015-12-01 发布于安徽
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ABSTRACT
isanew haSbeen usedin
Tiopronin,N-(2一mercaptopmpionyl)glycinedmg,w“ch widely
call and
clinicasmemedicinefor liverf嘶ction.It
improving comprehensiVelyemectiVely
curethe vimala11dalcoholic
thefhnctionjndexmarkaIld of
improve symptom hepatitis,be
takenas ofthe aIldthe andbeusedastIleantidote
pmtectingagents mdiomer印ychemoⅡlcrapy
of hasbeen is
mentalorsome it discovered eaSily to
heavy dnlgs.But tiopmnin decomposed
clinicwhemerinbⅢfer oras a
abIlIldallt in solutionsuch.Asresllltt11e
produce byproducts
aIldthe e虢ctwere madeane肺rtto
productpur埘declinesec嘶哆and destroyed.So、Ⅳe
tobemetalsalt.
modi匆tioproIlin
Aneralotof for andzmc
experiments,we丘ndprocessespreparingpOtaSsillrntiopronin
havetlle canbe
tiopronin,w量lichhigheryields,bett甜pmducts,simpleroperation髓ds佃1ply
into AndtheresIlltsofresearchindicatedthat
put opera:tionindus砸ally
andzinc to better
tioprollin,comp捌ngtiopromn,havestabili毋
Inthe stnJctIlresof
mealltime,t}le pOtassiumtiopronin甜ld西nctiopron曲areverined,
deteHninationof aIldchemical
throu曲the i招pHysicaJ constallts,o唱a11icanalysis,InnⅢed
MaSs
Spectmm(1R),Ul拄aⅥ01etSpectnun(uV),1H.NMR,13C.NMR
aj
X-rayDi珩action(Ⅺm),et
Attlle
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