《cJ mice.》.pdf

ZoologicalResearch35(4)：319—325 DOI：10．13918j／．issn．2095—8137．2014．4．319 AVP andGlu systemsinteracttoregulatelevelsofanxietyinBALB／ cJmice Xiao．LeiAN，Fa—DaoTAI CollegeofLifeSciences，ShaanxiNormalUniversity,Xian710062，China Abstract：Whiletherolesofglutamicacid(Glu)．argininevasopressin(AVP)andtheirrespectivereceptorsinanxietyhavebeen thoroughlyinvestigated，theeffectsofinteractionsamongGlu，N-methyl—D—asparticacid(NMDA1receptor, anda-amino．3． hydroxy一5一methylisoxazole一4一propionicacid(AMPA、receptoronanxieyt arestillunclear．Inthepresentstudy,theagonistand antagonistoftheNMDAreceptorandAMPArecepto~aswel1astheantagonistofAvPV1receptorfVlaR)werein~oducedinto BALB／cJmicebyintracerebroventricularmicroinjection，andthenaxieyt．1ikebehaviorsofthemicewereevaluatedbyopenfieldand elevatedplus—mazetests．ComparedwithC57BL／6mice．BALB／cJmicedisplayedhigherlevelsofanxieyt．1ikebehavior．Significnat anxiolyticeffectswerefoundintheNMDAreceptornatagonist(MK．801)andtheAMPAreceptororV1aRantagonist(SSRI49415)， aswellascombinationsofAVP／MK-801andSSRI49415／DNQX．Theseresultsindicatedthatanxiety．1ikebehaviorsexpressedin BALB／CJmicemaybeduetoacoordinationdisorderamongglutamate．NMDA receptor,AMPA recepto~AVPandV1aR．resulting intheup—regulationoftheNMDA receptorandV1aR naddown．regulationoftheAM PA receptor．Howeve~becausehteAMPA receptorcanexecuteitsanxiolyticfunctionbysuppressingAVPandV1aR．wecannotexcludethepossibilityoftheNMDA receptor beingactivatedbyAVPactingonVlaR． Keywords：Anxieyt；AMPAreceptor；NMDAreceptor；AVP；VlaR Manyhypotheseshavebeenproposedinregardsto receptorinducesanxietyordepression(Hashimoto，2011； thepathogenesisofanxiety e．g．monoamineneurotran- Skolnick．1999)．However,theAMPAreceptoragonistof smitterreceptordisorder．Glusystem disorder,andneu． Glu notonlyproducesremarkableanxiolyticandanti— ronalplasticity．However,allthesetheorieshavelimita． depressio