《Facile Conjugation of Heparin onto Titanium Surfaces via Dopamine Inspired Coatings for Improving Blood Compatibility.》.pdf
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《Facile Conjugation of Heparin onto Titanium Surfaces via Dopamine Inspired Coatings for Improving Blood Compatibility.》.pdf
832 Vot29No~ZZ~icai F.tcilleGoI Dnof飘印 ontoTitaniumSurfacesvia.
DOI 10.1007/sl1595-013-1005-5
FaclieConjugationofHeparinontoTitanium
SurfacesviaDopam ineInspiredCoatings
forImprovingBloodCompatibility
LIGuicai,2,”,XIEBiIg2,PANChangjiang~4’,YANGPing ,
DING H仰 gyan,HI NGNan2
fi.JiangsuProvincialKeyLaboratoryforInterventionalMedicalDevices,HuaiyinInstituteofTechnology,Huaian223003,China,2.Key
Lab.forAdvancedTechnologiesofMaterials,Min~tryofEducation,SouthwestJiaotongUniversity,Chengdu610031,China;3.Jiangsu
KeyLaboratoryofNeuroregeneration,NantongUniversity,Nantong226001,China;4.CollegeofBioengineering,ChongqingUniversity,
Chongqing400044,China)
Abstract:Immobilizationofheparinonbiomaterialssurfacehasbeenproventobeaneffective
strategyforpreventingthrombusofrmation.However,theproceduresofmostimmobilizationmethods
(physicaladsorption,covalentlinkage.electrostaticinteraction)arecomplicatedandtime—consuming.Inthe
presentstudy,heparinwithvariousconcentrationsimmobilizedonatitanium (Ti)substrateviapolydopamine
layerforimprovingbloodcompatibilitywasinvestigated.Watercontactanglemeasurementshowedthatthe
immobilizationofhepafinresultedin anincreaseofthehydrophilicity.X—rayphotoelectron spectroscopy
(XPS1andTbluidineBlueO (TBO1testsdisplayedhtatthehepafinmoleculesweresuccessfullyimmobilized
onTisurface.Theevaluationsofbloodcompatibiliyt (hemolysisrateAPTT,plateletadhesionandactivation,
fibrinogenconformationalchange)showedthattheimmobilizationofheparindecreasedhemolysisrate,
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