20章解热抗炎药151010.ppt

* * nausea(恶心) vomiting(呕吐) bleeding(出血) 1. Gastrointestinal reactions: gastric ulcer (胃溃疡) Stimulates gastric mucosa directly (直接刺激胃粘膜) 【 Adverse reactions】 （＋）CTZ （-）PG synthesis Prevention ：餐后服、同服抗酸药、肠溶片 * 2. Disturbance of blood coagulation(凝血障碍) 1)（-）TXA2 synthesis→（-）platelet aggregation (抑制血小板聚集) 2）at high doses →（-）prothrombin formation (大剂量抑制凝血酶原形成) Prevention and treatment (防治)：Vitamin K * 3. Allergic reactions (过敏反应) 花生四烯酸 环氧酶 PG 支气管扩张 脂氧酶 白三烯 支气管收缩 Aspirin(-) urticaria(荨麻疹), angioedema(血管神经性水肿), allergic shock , aspirin asthma(“阿司匹林哮喘”) 肾上腺素无效 *