《Compensatory function of bradykinin B1 receptor in the inhibitory effect of captopril on cardiomyocyte hypertrophy and cardiac fibroblast proliferation in neonatal rats》.pdfVIP
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《Compensatory function of bradykinin B1 receptor in the inhibitory effect of captopril on cardiomyocyte hypertrophy and cardiac fibroblast proliferation in neonatal rats》.pdf
1220 ChinMedJ
article
Original
functionof inthe
Compensatory B1
bradykininreceptor
effectof on andcardiac
captoprilcardiomyocyte
hypertrophy
fibroblast inneonatalrats
proliferation
ZOU XU
Jun,REN Dan,WANGand
Jiang-hua,FENGHong Jiang
Keywords:bradykinin;captopril;cardiacfibroblast;cardiomyocyte
ontwo and activationof mediates
BackgroundBradykinin(BK)acts Ba,and B2
mainly rece}ptorsubtypes:B1 receptor
themost
well—known effectsof rolethat
cardioprotectiveangiotensinconvertingenzyme
BI inACEihasnotbeen defined.WeexaminedtheroleofB1 inthe effectofACE
receptorplays fully receptorinhibitory
inhibitor onrat andcardiacfibroblast induced
captoprilcardiomyocytehypertrophy proliferationby II)
and its mechanism.
exploredpossible
MethodsNeonataI andcardiac treatedwith
fibroblasts(CFs)were
cardiomyocytes randomly AnglI,captopril,B2
receptorantagonist(HOE-140)andB1 orin
receptorantagonist(des—Ar910Leu。一kallidin)alone
was
usedtoevaluatecelI and content.Nitric intracellular
cytometry cycle,sizeprotein oxide(NO)and
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