《MicroRNA对胚胎干细胞的多能性网络调控 The effect of microRNAs on the regulatory network of pluripotency in embryonic stem cells》.pdfVIP

瞳f{}HEREDITAS(Beijing)2013年10月，35(10)：1153—1166 ISSN0253-9772 www．chinagene．cn 综 述 DoI：10．3724／SP．J．1005．2013．01153 MicroRNA对胚胎干细胞的多能性网络调控 白银山，李莉，卫恒习，朱翠，张守全 华南农业大学动物科学学院，动物基因组与分子育种广东省重点实验室，广州510642 stem 摘要：胚胎干细胞(Embryoniccells，ESCs)是一类能够无限增殖和诱导分化为多种类型细胞的千细胞。 用。MiRNA可以通过对ESCs多能性网络中的转录因子、细胞周期、表观遗传学、信号转导等方面调控，促使 对ESCs多能性网络调控作用等内容。 关键词：ESCs；miRNA；多能性：调控 TheeffectofmicroRNAsonthe networkof regulatory pluripotency in stemcells embryonic BAI Yin-Shan，LI Li，WEIHeng—Xi，ZHUCui，ZHANGShou·Quan ProvincialLab GenomicsandMolecular China Key Science，South Guangdong ofAgro-Animal Breeding，CollegeofAnimal Agricultural 510642，China University,Guangzhou stem stemcells their to characterized self-renewandtheir Abstract：Embryoniccells(ESCs)arepluripotent by ability todifferentiateintoallcell asmall RNA can moleculewhich pluripotency types．MicroRNA(miRNA)isnon—coding regu— late and also rolesin transcri[Itionalpost-transcriptionalgeneexpression，andmay playsignificantregulatingproliferation anddifferentiationofESCs．Themaintenanceof inESCs involvea networkof factors pluripotencymay regulatory many and includesESCs modifica- miRNA，which factors，cell pathwaysregulatedby transcription cycleregulation，epigenefic tionsaswellasintracelluartransduction．Thisreview elaboratesthe ofmiRNA．themiRNAfami- signal mainly biogen