《5-脂氧化酶、白三烯在动脉粥样硬化大鼠主动脉中的表达》.pdfVIP

125—03 ·论 文章编号：1001—5949(2011)12—1 著· 5一脂氧化酶、白三烯在动脉粥样硬化 大鼠主动脉中的表达 李丽芳，李晓霞，滕晓芸，薛华，姚成立 [摘要】 脉及血液中的表达及其意义。方法选取正常雄性SD大鼠25只，随机分为正常对照组和动脉粥样硬化组。正常 对照组普通饲料喂养，动脉粥样硬化组高脂饲料喂养建立动脉粥样硬化大鼠模型，14周后处死大鼠，采血，全自动 生化仪检测血脂，ELISA法检测血清及主动脉中5一脂氧化酶、白三烯B4、自三烯C4的含量。结果动脉粥样硬 化组血脂较正常组明显升高(P0．01)，动脉粥样硬化组血液中及主动脉中5一脂氧化酶、白三烯B4、白三烯c4 一【D／L1葛通路可能是动脉粥样硬化潜在的干预靶点。 [关键词】 动脉粥样硬化；5一脂氧化酶；白三烯；大鼠 [中圈分类号]R543．5[文献标识码】A of andleukotrleneinaortaofatheroseleroticrats Expression5一Hpoxygenase LiZ扣，lg，LiXiaoxia，死，lgXiaoyun，et吐 To theabnormal of inaortaandbloodofAthemsclerotic [Abstract]Obje删ive 5一LO，LTB4，LTC4 rata，dis- prove expression the rolein Methods normalSDmtsweredividedintotwo CUSS of5一LO／LTs meaning AtherescleresisoTwenty—five groupsrandomly， onewasnormalcontrol otherWRSatherosclemfic controlwasfedwithnormal group(n=10)，the group(n=15)。Normalgroup diet，Ath- WRSfedwith to fAter14 eroselerotic cholesteroldietinorderfoundthemodelofatheroscleroticratso groupgroup high weeks，bloodlipids were inbloodandaortaweremeasured Thelevelofblood inatherosclemtic measured，and5一LO，LTB4，LTCA too。Results lipid group normalcontrol levelof in and剐rtorofatheroseleroticratswas thanthatin 5一LO。LTB4，LTCAblood than w髓higher group。The higher thatinnormalcontrol The of inbloodandartorofatherese