《5-氨基水杨酸在炎症性肠病及其相关性结直肠癌中的作用新机制》.pdfVIP

Chin ·376· J 5-氨基水杨酸在炎症性肠病及其相关性结直肠癌中的作用新机制 杨彩虹+综述 吴正祥▲审校 安徽医科大学附属省立医院消化内科(230032) 5-ASA传统的抗炎机制足通过影响抑制前列腺索合成、调节各种细胞因子的产生而发挥抗炎作用的．新近研究发现5． ASA可能通过氧化物酶体增殖物激活受体(PPAR)-1途径发挥抗炎和抗瘤作用。本文就5．ASA的作用新机制作一简要 概述。 关键词 结肠炎，溃疡性； Cmhn病；结直肠肿瘤； 氨基水杨酸类； 过氧化物酶体增殖物激活受体 New ofMechaIIis脚of Understanding Ac伽nof5．AminosalicyIicAddinI曲a耽natoryBoweIDi蝴蛐andits ReIeVantColor∞talCancer An^Ⅱi胁iM谢 l，A～G瓤^o％形u历e，舻泐醪 脚硎胱m矿G琊￡roe胁?ro咖弘 Hospit越，AnhuiMedk越UT血)erS妨，H呼i(230032) to：WU Cor瑚pondenceZheng】【iang，E眦il．zxiangwu@126．com Abstract bowel subdividedintoulcerative Crohn’sdise鹳e Innammatorydisease(IBD)isclassically colitis叫C)and one“the classical used forthetreatmentofIBD．The (CD)．5-aminosalicylicacid(5一ASA)is anti—innammatoryagentstoday withIBDhaVea riskof colorectal of cancerand山e 5-AsA patients higher devel叩ing long-te肌usemaysigIlificandy reducetheriskof ofcoIorectalcancer．Theconventionalof actionof5．ASA development hypothesisanti．innammatory of includesmodulation andinhibitionofthe of and inflammatorycytokinepIDduction biosynthesis cytokines． prostaglandins Recentstudiesshowedthat5．ASA have may anti．in订ammatorvandanti．tumoreffectsviapemxisomepmliferation- activated aniclereviewedthe mechanism8ofactionof5-ASA． receptor(PPAR)-一ypathway，thi