《5-脂氧合酶激活蛋白基因多态性与缺血性卒中分子遗传学的研究进展》.pdfVIP

中国卒中杂志 2009年5月 第4卷 第5期 429 综述 ・ ・ 5-脂氧合酶激活蛋白基因多态性与 缺血性卒中分子遗传学的研究进展 徐佳亮，何志义，李楠 【摘要】 作者单位 缺血性卒中是一个复杂性状的多基因遗传病，遗传流行病学研究结果提示遗传变异决定了 其遗传易感性。近年来缺血性卒中遗传学的研究取得了长足的进展，通过连锁分析和关联分析陆续报 110001 辽宁省沈阳市 告了一些与缺血性卒中相关的新的易感基因。5-脂氧合酶激活蛋白（5-lipoxygenase activating protein， 中国医科大学附属第一 医院神经内科 ALOX5AP）基因是2004年鉴定出来的第一个与缺血性卒中密切相关的基因。本文就ALOX5AP基因多态性 通信作者 与缺血性卒中相关性的研究进展作一综述。 何志义 【关键词】 花生四烯酸盐；5－脂氧合酶；脑梗死；多态现象，遗传 hezhiyi0301@ Research Progress in ALOX5AP Gene Polymorphisms and Molecular Genetics of Ischemic Stroke XU Jia-Liang, HE Zhi-Yi, LI Nan. Department of Neurology, Affiliated First Hospital, China Medical University, Shenyang 110001, China 【 】 Abstract Ischemic stroke (IS) is a complex multifactorial disorder. The results of genetic epidemiological studies suggest that hereditary susceptibility is caused by genetic variants. In recent years much more progress in IS genetics research has been made through linkage and association analysis, and some new IS susceptible genes has been reported. 5-lipoxygenase activating protein (ALOX5AP) gene was identified as the first susceptible gene which was closely related with IS in 2004. In this article the research progress of genetics in IS and the association of ALOX5AP p