《Reduced Expression of Programmed Cell Death 5 Protein in Tissue of Human Prostate Cancer》.pdfVIP

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《Reduced Expression of Programmed Cell Death 5 Protein in Tissue of Human Prostate Cancer》.pdf

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《Reduced Expression of Programmed Cell Death 5 Protein in Tissue of Human Prostate Cancer》.pdf

Chin Med Sci J Vol. 24, No. 4 December 2009 P. 241-245 CHINESE MEDICAL SCIENCES JOURNAL ORIGINAL ARTICLE Reduced Expression of Programmed Cell Death 5 Protein in Tissue of Human Prostate Cancer 1 3 2 1 1 Yue-jun Du , Lin Xiong , Yan Lou , Wan-long Tan *, and Shao-bin Zheng 1Department of Urology, 2 Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China 3 First Department of Surgery, 187 Hospital of PLA, Haikou 571159, China Key words: prostate cancer; apoptosis ; programmed cell death 5 Objective To investigate the expression of programmed cell death 5 (PDCD5) in tissues of normal human prostate (NP), benign prostatic hyperplasia (BPH), and prostate cancer (PCa) in order to assess the clinical role of PDCD5 in PCa. Methods PDCD5 expression was determined by EnVision immunohistochemical staining in forma- lin-fixed and paraffin-embedded specimens obtained from 12 subjects with NP, 22 with BPH, and 22 with PCa. In addition, PCa cases were classified as low/middle-risk (Gleason sum≤7) and high-risk (Gleason sum7) on the basis of Gleason grade. Positive expression rates and intensity of PDCD5 protein were ob- served under light microscope and analyzed with computer imaging technique. Expression of PDCD5 was