《Solar thermochemical reactions Ⅲ A convenient one-pot synthesis of 1,2,4,5-tetrasubstituted imidazoles catalyzed by high surface area SiO2 and induced by solar thermal energy》.pdfVIP

Available online at Chinese Chemical Letters 20 (2009) 812–814 /locate/cclet Solar thermochemical reactions III: A convenient one-pot synthesis of 1,2,4,5-tetrasubstituted imidazoles catalyzed by high surface area SiO2 and induced by solar thermal energy Ramadan A. Mekheimer, Afaf M. Abdel Hameed, Seham A.A. Mansour, Kamal Usef Sadek * Chemistry Department, Faculty of Science, El-Minia University, El-Minia 61519, Egypt Received 8 December 2008 Abstract A simple, convenient and efficient method for the synthesis of 1,2,4,5-tetrasubstituted imidazole derivatives using benzoin, an aromatic aldehyde, an aromatic amine in the presence of ammonium acetate catalyzed by high surface area SiO2 and induced by free solar thermal energy was reported. # 2009 Kamal Usef Sadek. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. Keywords: One-pot synthesis; SiO ; Solar thermal energy; Tetrasubstituted imidazole 2 There is now a great demand for an alternative and freely available clean energy sources. Free solar energy does not require energy raw materials hence does not produce any associated pollutants and as a consequence is regarded as a clean reagent [1,2]. It is one key technology for solving world energy. Also, multi-component reactions (MCRs) are powerful tools in generating products in a single synthetic operation [3]. It enables straight forward access to structurally related, drug-like compounds and thereby facilitating lead generation. Such reactions have constituted an increasingly valuable approach to dru