BioRepair修復牙齒琺瑯質牙膏.ppt

* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * The surface Ca/P molar ratio determined by XPS analysis for demineralized enamel slabs before and after in vitro remineralization by brushing with toothpastes containing fluoride or CHA have been compared with the Ca/P molar ratio of CHA micro-clusters constituted of 100 nm sized microparticles. The enamel surface Ca/P molar ratio practically does not change before and after the brushing treatment with tooth pastes containing fluoride. This finding reveals how the only structural modification of enamel hydroxyapatite induced by fluoride is restricted to a partial hydroxyl group replacement by fluoride ions without affecting appreciably the Ca and phosphate structural network. On the contrary, enamel slabs after the brushing treatment with the toothpaste containing synthesised CHA micro-clusters of 100 nm sized microparticles the enamel slabs exhibit a surface Ca/P molar ratio very close to that of the synthetic CHA micro-clusters of 100 nm sized microparticles. The results highlight that biomimetic nano sized CHA microparticles produce an apatite coating deposition on the enamel surface. An advantage of the 100 nm sized synthetic building block respect the 20 nm sized in binding on to the enamel surface has been appreciated, but it can be ascribed to a different and more suitable micro-cluster aggregation. 在體外用含氟或CHA的牙膏刷牙進行礦化之前及之後的脫礦的琺瑯質磚的表面鈣/P摩爾比用XPS分析所測得的與用由100奈米大小的微粒所構成的CHA微集群相比。在用含氟牙膏刷之前和之後琺瑯質表面的鈣/P摩爾比例幾乎沒改變。 這一發現揭示為何在氟的誘導下琺瑯質的羥基磷灰石只有結構的修飾且只局限於一部分氫氧根/羥基被氟離子取代而卻不會很明顯地影響鈣及磷酸鹽的結構網路。相反地，用由100奈米大小的微粒建構的CHA微集群的牙膏刷過之後的琺瑯質磚其展示出在表面上的鈣/P摩爾比非常接近那個由100奈米大小構建合成CHA微集群表面上的鈣/P摩爾比。這結果揭示出仿生奈米大小的CHA微粒產生一磷灰石塗層沉積在琺瑯質的表面上。與20奈米大小的微粒固定在琺瑯質表面上的一樣，也感謝100奈米大小合成的構建塊的這一優勢，但它可以歸因於不同的或更合適的微粒聚集群。 * * Fig. 10. XRD patterns of enamel after brushing treatment with: water (d), fluoride containing toothpaste (c), CHA microclusters containing toothpaste (b) and XRD patterns of synthetic CHA microclusters (a). * in