新型pH敏感型药物缓释系统%3f介孔硅掺杂的海藻酸钠%2f壳聚糖凝胶球的制备，难溶性药物的负载和释放研究.pdfVIP

药物的释放在SGF 中符合Higuchi 模型，在SIF 中符合Ritger-peppas 模型，药物的释放 机制为non-Fickian 扩散行为控制释药，即以药物扩散为主，兼有骨架溶蚀协同作用。 本工作制备的介孔硅掺杂的海藻酸钠/壳聚糖凝胶球系统成功实现了在胃肠道中对 药物的pH 控制释放。此凝胶球能克服某些药物口服时对胃刺激性大、易引起胃部严重 不良反应的缺点，能保护治疗肠道疾病的药物不被胃吸收或被胃酶所破坏，延长疗效， 提高药物稳定性。而且此凝胶球制备简单、周期短、成本低。我们相信此新型pH 敏感 药物缓释凝胶球系统在肠道药物缓释中的应用会有很大的发展潜力。 关键词：介孔硅，海藻酸钠，壳聚糖，凝胶球，pH 敏感，缓慢释放 II ABSTRACT Mesoporous silica materials are known as ideal drug supports due to their high pore volume and high surface area, good biocompatibilities, non toxicity and pharmacological activity. Mesoporous silica materials facilitate the adsorption of high pharmaceutical drug amount whether the drug is hydrophilic or poorly soluble drug, and mesoporous materials can achieve sustained/controlled drug delivery. The human body is a complex environmental system, and exhibits variations in pH in different parts, pH-sensitive drug delivery system is important for human. Alginate/chitosan hydrogels (AC hydrogels) is pH-sensitive, which can achieve pH-sensitive controlled drug delivery. This paper proposed a strategy to combine mesoporous silica and AC hydrogel together to prepare a novel pH-sensitive and sustainable drug delivery system-AC gel beads doped by different mesoporous silica (AC/MPS gel beads) for pH-sensitive sustainable drug release system, this system not only overcome the shortcoming of the two types of materials, but also have special characteristic, and the preparation is simple and convenient. we have mainly studied the contents as follows: 1. In this paper, mesoporous silica MCM-41 and SBA-15, which have different pore size: the pore size of MCM-41 and SBA-15 is 3.6nm and 9.8nm respectively, were synthesized and functionalized by amine group via post-grafting synthesis. Indomethacin(IDM), a poorly soluble drug, as the mode