贫血与卒中预后1.docVIP

J Clin Neurosci.?2013 Jan;20(1):37-42. doi: 10.1016/j.jocn.2012.05.020. Epub 2012 Oct 30. A cohort study of patients with?anemia?on admission and fatality after acute ischemic?stroke. Hao Z1,?Wu B,?Wang D,?Lin S,?Tao W,?Liu M. Author information 1The?Stroke?Clinical Research Unit, Department of Neurology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu 610041, China. Abstract Reduced blood hemoglobin levels may impair oxygen delivery to the brain and hinder neurological improvement. We prospectively registered consecutively hospitalized Chinese patients with acute ischemic?stroke?within 24 hours of symptom onset to investigate whether?anemia?on admission influences case fatality and functional outcome of acute ischemic?stroke?at 12 months.?Anemia?was defined as a blood hemoglobin level of 120 g/L for women, and 130 g/L for men. We also performed a meta-analysis of the current cohort and previously published studies. We included 1176 patients, of whom 351 patients (29.8%) had?anemia. Age (odds ratio [OR]=1.02, 95% confidence interval [CI]: 1.01-1.03), history of hemorrhagicstroke?(OR=3.34, 95% CI: 1.17-9.56), alcohol consumption (OR=0.59, 95% CI: 0.38-0.92), and estimated glomerular filtration rate 60 mL/minute per 1.73 m(2) (OR=1.34, 95% CI: 1.00-1.80) were the independent predictors of?anemia. After adjustment for potential confounders,?anemia?on admission was shown to be an independent predictor of death at discharge and at 12 months (OR=1.66, 95% CI, 1.08-2.56; OR=1.56, 95% CI, 1.05-2.31). A meta-analysis of six included studies involving 3810 participants confirmed that?anemia?on admission was an independent predictor of death at the end of follow-up (OR=1.67, 95% CI, 1.25-2.08). Further studies are required to confirm these findings. Copyright ? 2012 Elsevier Ltd. All rights reserved. BMC Neurol.?2010 Apr 9;10:22. doi: 10.1186/1471-2377-10-22. Anemia?status, hemoglobin concentratio