硕士生学位论文.docVIP

硕士学位论文 选题名称 基于PCL-1250/LDI的生物可降解聚氨酯的合成、表征及电纺丝研究 学 号 姓 名 范晓非 导 师 张爱英 研究方向 生物医用材料 二级学科 材料学 一级学科 材料科学与工程 学 院 材料学院 2010 年 6 月9 日 摘 要 聚氨酯通常是由软段和硬段交替组成的多嵌段共聚物，分子链中所含有的氨基甲酸酯基团(—NHCOO—)能使分子内与分子间产生强烈的氢键相互作用，适当的软、硬段结构及其比例，可以获得良好的物理机械性能。与此同时，聚氨酯还具有优良的抗凝血性能和生物相容性，以及无过敏反应等性能，人工心脏、人工血管、人工导管等。随着组织工程概念的提出和发展，聚氨酯材料不能生物降解的日益引起人们的关注。首先成ε-己内酯)二元醇(PCL)为软段的聚氨酯材料。采用GPC、核磁、红外、DSC、力学性能测试等方法对所制备得到的可降解聚氨酯样品进行结构和性能表征 关键词：聚氨酯；赖氨酸二异氰酸酯 Abstract The polyurethane (PU) are a kind of multi-block copolymers composed of soft segment and hard segment, in which the inherent carbaminate groups (—NHCOO—) can form a variety of intramolecular and intermolecular hydrogen bonds. A suitable choice of soft and hard segment structure and the proportion can provide the PUs with good physical mechanical properties, e.g. fine toughness and elasticity, wearable, chemical resistance, water resistance, good process property and so on. At the same time, the PU also have the anti-coagulant and biocompatible abilities. Consequently, they are widely utilized in the biomedical area, e.g. heart valve, artificial blood vessel, artificial skin, bone adhesive and so on. It is highly concerned that the early PUs showed no bio-degradable along with the incomming and development of the concept of tissue engineering. In this study, a kind of biodegradable PU was synthesized and characterized to study the relations between the structure and the properties. PU non-woven menbranes were fibracated by electrospinning. and at the same time electrospinning procossing of the PUs was also investigated. Firstly, a kind of biodegradable and biocompatible polyurethanes was prepared by the step-growth polymerization of L-lysine ethyl ester diisocyanate (LDI) as hard segment, poly(ε-capro- lactone) diol (PCL) as soft segment and L-lysine ethyl ester (Lysine)/1,4- Butanediol as chain extender. The PUs synthesized were characterized by GPC, FTIR, DSC and tensile tests. The results showed that the tensile stren